The Animals That Echolocate – Including Us
These single-module NRPS proteins include Ebony, from several bugs including Drosophila melanogaster, and ACSF-U26, from vertebrates together with people (Fig. 6A). Ebony is among the oldest recognized NRPS genes, though it was not characterized as such until pioneering work in the 2000s . It was proposed that Ebony is concerned in regulating histamine and other neurotransmitters, covalently modifying and inactivating them . The purified protein’s A area uses ATP to activate β-alanine, which is then conjugated to histamine, dopamine, and varied other amine ligands .
Giants Of The Animal World
tasmaniensis, that is carried out by a PLP-dependent sulfoxide lyase, OvoB . This is once more catalyzed by OvoA, utilizing its C-terminal SAM-dependent methyltransferase area (Fig. 7) . Until recently, animal NRPS proteins were considered restricted to a few examples that converge with primary metabolism .
A PKS from mallard geese was partially … Read More